A relativistic spin operator cannot be uniquely defined within relativistic quantum mechanics. Previously, different proper relativistic spin operators have been proposed, such as spin operators of the Foldy-Wouthuysen and Pryce type, that both commute with the free-particle Dirac Hamiltonian and represent constants of motion... Here we consider the dynamics of a relativistic electron spin in an external electromagnetic field. We use two different Hamiltonians to derive the corresponding spin dynamics. These two are: (a) the Dirac Hamiltonian in presence of an external field, (b) the semirelativistic expansion of the same. Considering the Foldy-Wouthuysen and Pryce spin operators we show that these lead to different spin dynamics in an external electromagnetic field, which offers possibilities to distinguish their action. We find that the dynamics of both spin operators involve spin-dependent and spin-independent terms, however, the Foldy-Wouthuysen spin dynamics additionally accounts for the relativistic particle-antiparticle coupling. We conclude that the Pryce spin operator provides a suitable description of the relativistic spin dynamics in a weak-to-intermediate external field, whereas the Foldy-Wouthuysen spin operator is more suitable in the strong field regime. (read more)