Extreme bendability of DNA double helix due to bending asymmetry

23 May 2015 Salari Hossein Eslami-Mossallam B. Naderi M. S. Ejtehadi M. R.

Experimental data of the DNA cyclization (J-factor) at short length scales, as a way to study the elastic behavior of tightly bent DNA, exceed the theoretical expectation based on the wormlike chain (WLC) model by several orders of magnitude. Here, we propose that asymmetric bending rigidity of the double helix in the groove direction can be responsible for extreme bendability of DNA at short length scales and it also facilitates DNA loop formation at these lengths... (read more)

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Categories


  • SOFT CONDENSED MATTER
  • STATISTICAL MECHANICS
  • BIOLOGICAL PHYSICS