1 code implementation • 2 May 2024 • Guillermo M. Besne, Nathan Evans, Mariella Panagiotopoulou, Billy Smith, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Mathew Walker, Peter N. Taylor, Chris Thornton, Yujiang Wang
Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, despite their potential impact on research and clinical practice.
no code implementations • 10 Oct 2023 • Csaba Kozma, Gabrielle Schroeder, Tom Owen, Jane de Tisi, Andrew W. McEvoy, Anna Miserocchi, John Duncan, Yujiang Wang, Peter N. Taylor
Combining periodic and aperiodic abnormalities improved performance, similar to the complete band power approach.
no code implementations • 13 Sep 2023 • Mariella Panagiotopoulou, Christopher Thornton, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Sarah J Gascoigne, Andrew W McEvoy, Anna Miserocchi, Billy C Smith, Jane de Tisi, Peter N Taylor, Yujiang Wang
Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain.
no code implementations • 11 Apr 2023 • Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall, Fahmida A. Chowdhury, Beate Diehl, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Finally, we assessed if the implantation of electrodes in abnormal tissue, and resection of the strongest abnormalities determined by MEG and iEEG explained surgical outcome.
no code implementations • 11 Apr 2023 • Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall, Jonathan J. Horsley, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
We quantified the spatial overlap between the abnormality cluster and subsequent resection, hypothesising a greater overlap in seizure-free patients.
no code implementations • 6 Apr 2023 • Jonathan J Horsley, Rhys H Thomas, Fahmida A Chowdhury, Beate Diehl, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B Vos, Matthew C Walker, Gavin P Winston, John S Duncan, Yujiang Wang, Peter N Taylor
Here, we investigate whether structural connectivity abnormalities, inferred from dMRI, may be used in conjunction with functional iEEG abnormalities to aid localisation and resection of the epileptogenic zone (EZ), and improve surgical outcomes in epilepsy.
no code implementations • 11 Feb 2023 • Yujiang Wang, Gabrielle M Schroeder, Jonathan J Horsley, Mariella Panagiotopoulou, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Peter N Taylor
To assess the localising value of band power abnormality, we computed DRS - a measure of how different the surgically resected and spared tissue were in terms of band power abnormalities - over time.
no code implementations • 13 Jul 2022 • Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Resting-state MEG data were acquired for 70 healthy controls and 32 patients with refractory neocortical epilepsy.
no code implementations • 17 Apr 2022 • Nishant Sinha, John S. Duncan, Beate Diehl, Fahmida A. Chowdhury, Jane de Tisi, Anna Miserocchi, Andrew W. McEvoy, Kathryn A. Davis, Sjoerd B. Vos, Gavin P. Winston, Yujiang Wang, Peter N. Taylor
We investigated pre-operative structure-function coupling at two spatial scales a) at the global iEEG network level and b) at the resolution of individual iEEG electrode contacts using virtual surgeries.
no code implementations • 10 May 2021 • Peter N Taylor, Christoforos A Papasavvas, Thomas W Owen, Gabrielle M Schroeder, Frances E Hutchings, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B Vos, Matthew C Walker, Yujiang Wang
We then compared interictal recordings from 62 patients with epilepsy to the normative map to identify abnormal regions.