no code implementations • 10 Apr 2023 • Mengjin Dong, Long Xie, Sandhitsu R. Das, Jiancong Wang, Laura E. M. Wisse, Robin deFlores, David A. Wolk, Paul A. Yushkevich
Longitudinal assessment of brain atrophy, particularly in the hippocampus, is a well-studied biomarker for neurodegenerative diseases, such as Alzheimer's disease (AD).
2 code implementations • 21 Mar 2023 • Pulkit Khandelwal, Michael Tran Duong, Shokufeh Sadaghiani, Sydney Lim, Amanda Denning, Eunice Chung, Sadhana Ravikumar, Sanaz Arezoumandan, Claire Peterson, Madigan Bedard, Noah Capp, Ranjit Ittyerah, Elyse Migdal, Grace Choi, Emily Kopp, Bridget Loja, Eusha Hasan, Jiacheng Li, Alejandra Bahena, Karthik Prabhakaran, Gabor Mizsei, Marianna Gabrielyan, Theresa Schuck, Winifred Trotman, John Robinson, Daniel Ohm, Edward B. Lee, John Q. Trojanowski, Corey McMillan, Murray Grossman, David J. Irwin, John Detre, M. Dylan Tisdall, Sandhitsu R. Das, Laura E. M. Wisse, David A. Wolk, Paul A. Yushkevich
Postmortem MRI allows brain anatomy to be examined at high resolution and to link pathology measures with morphometric measurements.
no code implementations • 1 Mar 2023 • Sadhana Ravikumar, Ranjit Ittyerah, Sydney Lim, Long Xie, Sandhitsu Das, Pulkit Khandelwal, Laura E. M. Wisse, Madigan L. Bedard, John L. Robinson, Terry Schuck, Murray Grossman, John Q. Trojanowski, Edward B. Lee, M. Dylan Tisdall, Karthik Prabhakaran, John A. Detre, David J. Irwin, Winifred Trotman, Gabor Mizsei, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzono Martin, Maria del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria del Pilar Marcos Rabal, Sandra Cebada-Sánchez, José Carlos Delgado González, Carlos de la Rosa-Prieto, Marta Córcoles Parada, David A. Wolk, Ricardo Insausti, Paul A. Yushkevich
When developing tools for automated cortical segmentation, the ability to produce topologically correct segmentations is important in order to compute geometrically valid morphometry measures.
1 code implementation • 25 Jan 2023 • Zhijian Yang, Junhao Wen, Ahmed Abdulkadir, Yuhan Cui, Guray Erus, Elizabeth Mamourian, Randa Melhem, Dhivya Srinivasan, Sindhuja T. Govindarajan, Jiong Chen, Mohamad Habes, Colin L. Masters, Paul Maruff, Jurgen Fripp, Luigi Ferrucci, Marilyn S. Albert, Sterling C. Johnson, John C. Morris, Pamela Lamontagne, Daniel S. Marcus, Tammie L. S. Benzinger, David A. Wolk, Li Shen, Jingxuan Bao, Susan M. Resnick, Haochang Shou, Ilya M. Nasrallah, Christos Davatzikos
Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases.
1 code implementation • 20 Oct 2021 • Junhao Wen, Cynthia H. Y. Fu, Duygu Tosun, Yogasudha Veturi, Zhijian Yang, Ahmed Abdulkadir, Elizabeth Mamourian, Dhivya Srinivasan, Jingxuan Bao, Guray Erus, Haochang Shou, Mohamad Habes, Jimit Doshi, Erdem Varol, Scott R Mackin, Aristeidis Sotiras, Yong Fan, Andrew J. Saykin, Yvette I. Sheline, Li Shen, Marylyn D. Ritchie, David A. Wolk, Marilyn Albert, Susan M. Resnick, Christos Davatzikos
We sought to delineate, cross-sectionally and longitudinally, disease-related heterogeneity in LLD linked to neuroanatomy, cognitive functioning, clinical symptomatology, and genetic profiles.
2 code implementations • 14 Oct 2021 • Pulkit Khandelwal, Shokufeh Sadaghiani, Michael Tran Duong, Sadhana Ravikumar, Sydney Lim, Sanaz Arezoumandan, Claire Peterson, Eunice Chung, Madigan Bedard, Noah Capp, Ranjit Ittyerah, Elyse Migdal, Grace Choi, Emily Kopp, Bridget Loja, Eusha Hasan, Jiacheng Li, Karthik Prabhakaran, Gabor Mizsei, Marianna Gabrielyan, Theresa Schuck, John Robinson, Daniel Ohm, Edward Lee, John Q. Trojanowski, Corey McMillan, Murray Grossman, David Irwin, M. Dylan Tisdall, Sandhitsu R. Das, Laura E. M. Wisse, David A. Wolk, Paul A. Yushkevich
Ex vivo MRI of the brain provides remarkable advantages over in vivo MRI for visualizing and characterizing detailed neuroanatomy.
no code implementations • 8 Sep 2021 • Gyujoon Hwang, Ahmed Abdulkadir, Guray Erus, Mohamad Habes, Raymond Pomponio, Haochang Shou, Jimit Doshi, Elizabeth Mamourian, Tanweer Rashid, Murat Bilgel, Yong Fan, Aristeidis Sotiras, Dhivya Srinivasan, John C. Morris, Daniel Marcus, Marilyn S. Albert, Nick R. Bryan, Susan M. Resnick, Ilya M. Nasrallah, Christos Davatzikos, David A. Wolk
First, a subset of AD patients and CN adults were selected based purely on clinical diagnoses to train SPARE-BA1 (regression of age using CN individuals) and SPARE-AD1 (classification of CN versus AD).
no code implementations • 19 Mar 2021 • Long Xie, Laura E. M. Wisse, Jiancong Wang, Sadhana Ravikumar, Trevor Glenn, Anica Luther, Sydney Lim, David A. Wolk, Paul A. Yushkevich
A hybrid method that integrates the high accuracy of DL and good generalizability of MAS is highly desired and could play an important role in segmentation problems where manually labeled data is hard to generate.
no code implementations • 24 Oct 2020 • Mengjin Dong, Long Xie, Sandhitsu R. Das, Jiancong Wang, Laura E. M. Wisse, Robin deFlores, David A. Wolk, Paul Yushkevich
However, longitudinal MRI change measures can be confounded by non-biological factors, such as different degrees of head motion and susceptibility artifact between pairs of MRI scans.
no code implementations • 11 Oct 2020 • Vishnu M. Bashyam, Jimit Doshi, Guray Erus, Dhivya Srinivasan, Ahmed Abdulkadir, Mohamad Habes, Yong Fan, Colin L. Masters, Paul Maruff, Chuanjun Zhuo, Henry Völzke, Sterling C. Johnson, Jurgen Fripp, Nikolaos Koutsouleris, Theodore D. Satterthwaite, Daniel H. Wolf, Raquel E. Gur, Ruben C. Gur, John C. Morris, Marilyn S. Albert, Hans J. Grabe, Susan M. Resnick, R. Nick Bryan, David A. Wolk, Haochang Shou, Ilya M. Nasrallah, Christos Davatzikos
Conventional and deep learning-based methods have shown great potential in the medical imaging domain, as means for deriving diagnostic, prognostic, and predictive biomarkers, and by contributing to precision medicine.
no code implementations • 15 Apr 2019 • Hongming Li, Mohamad Habes, David A. Wolk, Yong Fan
Introduction: It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease (AD) dementia.