no code implementations • 17 Apr 2024 • Yakun Li, Xiyin Liang, Jinzhi Lei
Gene regulatory network dynamics are pivotal in controlling stem cell regeneration and cell type transitions.
no code implementations • 17 Apr 2024 • Xue Liu, Yue Deng, Jingying Huang, Yuhong Zhang, Jinzhi Lei
The global public health landscape is perpetually challenged by the looming threat of infectious diseases.
2 code implementations • 9 Apr 2024 • Shengze Dong, Zhuorui Cui, Ding Liu, Jinzhi Lei
The method is a neural network constructed based on Denoising Diffusion Probabilistic Models (DDPMs) and Diffusion Transformers (DiTs).
no code implementations • 14 Sep 2023 • Jinzhi Lei
In developing the mathematical models of stem cell regeneration and tissue development, cell division is the core process connecting different scale biological processes and leading to changes in cell population number and the epigenetic state of cells.
1 code implementation • 13 Sep 2023 • Rongsheng Huang, Qiaojun Situ, Jinzhi Lei
Through model simulations, we demonstrate that random inheritance of epigenetic states during cell divisions can spontaneously induce cell differentiation, dedifferentiation, and transdifferentiation.
no code implementations • 16 Apr 2020 • Yusong Ye, Zhuoqin Yang, Jinzhi Lei
Induced pluripotent stem cells (iPSCs) provide a great model to study the process of reprogramming and differentiation of stem cells.
no code implementations • 15 Feb 2020 • Yusong Ye, Zhuoqin Yang, Jinzhi Lei
In this study, we developed a computational model of enhancer methylation inheritance to study the dynamics of genome-scale DNA methylation reprogramming during exit from pluripotency.
no code implementations • 19 Aug 2019 • Jinzhi Lei
In this paper, we propose a general mathematical model framework for the evolutionary dynamics of cancer with plasticity and heterogeneity in cancer cells.