Multi-level Interaction Modeling for Protein Mutational Effect Prediction

no code implementations • 28 May 2024 • Yuanle Mo, Xin Hong, Bowen Gao, Yinjun Jia, Yanyan Lan

Protein-protein interactions are central mediators in many biological processes.

ProFSA: Self-supervised Pocket Pretraining via Protein Fragment-Surroundings Alignment

no code implementations • 11 Oct 2023 • Bowen Gao, Yinjun Jia, Yuanle Mo, Yuyan Ni, WeiYing Ma, ZhiMing Ma, Yanyan Lan

Pocket representations play a vital role in various biomedical applications, such as druggability estimation, ligand affinity prediction, and de novo drug design.