no code implementations • 17 Jul 2023 • Fan Fan, Georgia Martinez, Thomas Desilvio, John Shin, Yijiang Chen, Bangchen Wang, Takaya Ozeki, Maxime W. Lafarge, Viktor H. Koelzer, Laura Barisoni, Anant Madabhushi, Satish E. Viswanath, Andrew Janowczyk
Batch effects (BEs) refer to systematic technical differences in data collection unrelated to biological variations whose noise is shown to negatively impact machine learning (ML) model generalizability.
no code implementations • 13 Jul 2023 • Cedric Walker, Tasneem Talawalla, Robert Toth, Akhil Ambekar, Kien Rea, Oswin Chamian, Fan Fan, Sabina Berezowska, Sven Rottenberg, Anant Madabhushi, Marie Maillard, Laura Barisoni, Hugo Mark Horlings, Andrew Janowczyk
Using >100, 000 objects, we demonstrate a >7x improvement in labels per second over unaided labeling, with minimal impact on labeling accuracy, thus enabling high-throughput labeling of large datasets.
1 code implementation • 5 May 2023 • Chuang Zhu, ShengJie Liu, Zekuan Yu, Feng Xu, Arpit Aggarwal, Germán Corredor, Anant Madabhushi, Qixun Qu, Hongwei Fan, Fangda Li, Yueheng Li, Xianchao Guan, Yongbing Zhang, Vivek Kumar Singh, Farhan Akram, Md. Mostafa Kamal Sarker, Zhongyue Shi, Mulan Jin
For invasive breast cancer, immunohistochemical (IHC) techniques are often used to detect the expression level of human epidermal growth factor receptor-2 (HER2) in breast tissue to formulate a precise treatment plan.
no code implementations • 5 Oct 2022 • Nathaniel Braman, Prateek Prasanna, Kaustav Bera, Mehdi Alilou, Mohammadhadi Khorrami, Patrick Leo, Maryam Etesami, Manasa Vulchi, Paulette Turk, Amit Gupta, Prantesh Jain, Pingfu Fu, Nathan Pennell, Vamsidhar Velcheti, Jame Abraham, Donna Plecha, Anant Madabhushi
QuanTAV risk scores were prognostic of recurrence free survival in treatment cohorts chemotherapy for breast cancer (p=0. 002, HR=1. 25, 95% CI 1. 08-1. 44, C-index=. 66) and chemoradiation for NSCLC (p=0. 039, HR=1. 28, 95% CI 1. 01-1. 62, C-index=0. 66).
no code implementations • 12 Mar 2021 • Marwa Ismail, Prateek Prasanna, Kaustav Bera, Volodymyr Statsevych, Virginia Hill, Gagandeep Singh, Sasan Partovi, Niha Beig, Sean McGarry, Peter Laviolette, Manmeet Ahluwalia, Anant Madabhushi, Pallavi Tiwari
Our work is based on the rationale that highly aggressive tumors tend to grow uncontrollably, leading to pronounced biomechanical tissue deformations in the normal parenchyma, which when combined with local morphological differences in the tumor confines on MRI scans, will comprehensively capture tumor field effect.
1 code implementation • 6 Jan 2021 • Runtian Miao, Robert Toth, Yu Zhou, Anant Madabhushi, Andrew Janowczyk
Image based biomarker discovery typically requires an accurate segmentation of histologic structures (e. g., cell nuclei, tubules, epithelial regions) in digital pathology Whole Slide Images (WSI).
no code implementations • 2 Aug 2020 • S. Kevin Zhou, Hayit Greenspan, Christos Davatzikos, James S. Duncan, Bram van Ginneken, Anant Madabhushi, Jerry L. Prince, Daniel Rueckert, Ronald M. Summers
In this survey paper, we first present traits of medical imaging, highlight both clinical needs and technical challenges in medical imaging, and describe how emerging trends in deep learning are addressing these issues.
no code implementations • 16 Jun 2020 • Marwa Ismail, Virginia Hill, Volodymyr Statsevych, Evan Mason, Ramon Correa, Prateek Prasanna, Gagandeep Singh, Kaustav Bera, Rajat Thawani, Anant Madabhushi, Manmeet Ahluwalia, Pallavi Tiwari
In this study, 74 pre-treatment Glioblastoma MRI scans with PsP (33) and tumor recurrence (41) were analyzed.
1 code implementation • 10 Apr 2020 • Amir Reza Sadri, Andrew Janowczyk, Ren Zou, Ruchika Verma, Niha Beig, Jacob Antunes, Anant Madabhushi, Pallavi Tiwari, Satish E. Viswanath
We present MRQy, a new open-source quality control tool to (a) interrogate MRI cohorts for site- or equipment-based differences, and (b) quantify the impact of MRI artifacts on relative image quality; to help determine how to correct for these variations prior to model development.
no code implementations • 22 Jan 2020 • Nathaniel Braman, Mohammed El Adoui, Manasa Vulchi, Paulette Turk, Maryam Etesami, Pingfu Fu, Kaustav Bera, Stylianos Drisis, Vinay Varadan, Donna Plecha, Mohammed Benjelloun, Jame Abraham, Anant Madabhushi
In a retrospective study encompassing DCE-MRI data from a total of 157 HER2+ breast cancer patients from 5 institutions, we developed and validated a deep learning approach for predicting pathological complete response (pCR) to HER2-targeted NAC prior to treatment.
no code implementations • 21 Nov 2014 • Mitko Veta, Paul J. van Diest, Stefan M. Willems, Haibo Wang, Anant Madabhushi, Angel Cruz-Roa, Fabio Gonzalez, Anders B. L. Larsen, Jacob S. Vestergaard, Anders B. Dahl, Dan C. Cireşan, Jürgen Schmidhuber, Alessandro Giusti, Luca M. Gambardella, F. Boray Tek, Thomas Walter, Ching-Wei Wang, Satoshi Kondo, Bogdan J. Matuszewski, Frederic Precioso, Violet Snell, Josef Kittler, Teofilo E. de Campos, Adnan M. Khan, Nasir M. Rajpoot, Evdokia Arkoumani, Miangela M. Lacle, Max A. Viergever, Josien P. W. Pluim
The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers.