no code implementations • 29 Oct 2020 • Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova, Majlinda Lako, Nicholas G Parker, Anvar Shukurov
The aim of this chapter is to convey the importance and usefulness of mathematical modelling as a tool to achieve a deeper understanding of stem cell biology.
no code implementations • 20 Apr 2020 • Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova, Majlinda Lako, R A Barrio, A W Baggaley, Nicholas G Parker, Anvar Shukurov
The improved in-vitro regulation of human embryonic stem cell (hESC) pluripotency and differentiation trajectories is required for their promising clinical applications.
no code implementations • 17 May 2019 • Sirio Orozco-Fuentes, Irina Neganova, Laura E. Wadkin, Andrew W. Baggaley, Rafael A. Barrio, Majlinda Lako, Anvar Shukurov, Nicholas G. Parker
The gaps between the cells, which are present in small and medium sized colonies with $A \le 0. 6 \, \text{mm}^2$, disappear in large colonies ($A > 0. 6 \, \text{mm}^2$) due to the proliferation of the cells in the bulk.
no code implementations • 16 Apr 2019 • Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova, Sanja Bojic, Alex Laude, Majlina Lako, Nicholas G Parker, Anvar Shukurov
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have promising clinical applications which often rely on clonally-homogeneous cell populations.