1 code implementation • 19 Jul 2021 • Claire Miller, Edmund Crampin, James Osborne
In this paper we will investigate combining a (mass action) subcellular model of desquamation with a three dimensional (cell centre based) multicellular model of the interfollicular epidermis to better understand maintenance of epidermal thickness.
2 code implementations • 27 Nov 2018 • Claire Miller, Edmund Crampin, James Osborne
Using an established model of the inter-follicular epidermis we find there is a limit to the proliferative cell densities that can be maintained in the basal layer (the niche) if we do not include additional mechanisms to stop the loss of proliferative cells from the niche.
