no code implementations • 10 Nov 2023 • A. Zambon, R. Zecchina, G. Tiana
Our tool combines advancements in machine learning and statistical physics, providing new insights into the exploration of sequence landscapes where wide, flat minima coexist alongside a majority of narrower minima.
no code implementations • 14 Jun 2023 • E. Marchi, Y. Zhan, G. Tiana
With a simple polymeric model, we show that such a Rouse-like dynamics occurs when the parameters of the model are chosen so that contacts are local along the chain, while in presence of non-local contacts, we observe subdiffusion at short time scales with exponents smaller than 0. 5.
no code implementations • 8 Apr 2022 • M. Tajana, A. Trovato, G. Tiana
The native conformation of structured proteins is stabilized by a complex network of interactions.
1 code implementation • 14 May 2020 • M. Crippa, Y. Zhan, G. Tiana
By averaging out the position of the extruder along the chain, we build an effective equilibrium model capable of reproducing experimental contact maps based solely on the positions of extrusion--blocking proteins.