1 code implementation • 15 Dec 2023 • Hongsong Feng, Sean Cottrell, Yuta Hozumi, Guo-Wei Wei
Single-cell RNA sequencing (scRNA-seq) has emerged as a transformative technology, offering unparalleled insights into the intricate landscape of cellular diversity and gene expression dynamics.
no code implementations • 14 Aug 2023 • Rui Wang, Hongsong Feng, Guo-Wei Wei
This paper not only explores the integration of advanced AI in drug discovery but also reimagines the landscape by advocating for AI-powered chatbots as trailblazers in revolutionizing therapeutic innovation.
1 code implementation • 11 Jul 2023 • Long Chen, Jian Jiang, Bozheng Dou, Hongsong Feng, Jie Liu, Yueying Zhu, Bengong Zhang, Tianshou Zhou, Guo-Wei Wei
Pain is a significant global health issue, and the current treatment options for pain management have limitations in terms of effectiveness, side effects, and potential for addiction.
no code implementations • 13 Jun 2023 • Hongsong Feng, Rui Wang, Chang-Guo Zhan, Guo-Wei Wei
Opioid Use Disorder (OUD) has emerged as a significant global public health issue, with complex multifaceted conditions.
1 code implementation • 1 Mar 2023 • Hongsong Feng, Jian Jiang, Guo-Wei Wei
Using these predictors, we systematically analyzed the binding affinities of DrugBank compounds on four opioid receptors.
1 code implementation • 12 Jan 2023 • Hongsong Feng, Rana Elladki, Jian Jiang, Guo-Wei Wei
Despite that a few pharmacological agents have been approved for OUD treatment, the efficacy of said agents for OUD requires further improvement in order to provide safer and more effective pharmacological and psychosocial treatments.
1 code implementation • 27 Dec 2022 • Li Shen, Hongsong Feng, Yuchi Qiu, Guo-Wei Wei
Virtual screening (VS) is an essential technique for understanding biomolecular interactions, particularly, drug design and discovery.
1 code implementation • 2 Nov 2022 • Hongsong Feng, GuoWei Wei
We are particularly interested in the hERG-cardiotoxicity of compounds collected in the DrugBank database considering that many DrugBank compounds have been approved for therapeutic treatments or have high potential to become drugs.
1 code implementation • 1 Jan 2022 • Hongsong Feng, Kaifu Gao, Dong Chen, Alfred J Robison, Edmund Ellsworth, Guo-Wei Wei
Cocaine dependence is neurological and involves many interacting proteins in the interactome.