1 code implementation • 23 Nov 2022 • Michele Gentili, Leonardo Martini, Marialuisa Sponziello, Luca Becchetti
Motivation: Over the past decade, network-based approaches have proven useful in identifying disease modules within the human interactome, often providing insights into key mechanisms and guiding the quest for therapeutic targets.
no code implementations • 28 Oct 2022 • Leonardo Martini, Adriano Fazzone, Michele Gentili, Luca Becchetti, Brian Hobbs
Results: We present the Relations-Maximization Method, a dense module searching method to identify putative causal genes at GWAS loci through the generation of candidate sub-networks derived by integrating association signals from GWAS data into the gene co-regulation network.
no code implementations • 8 Jul 2021 • Leonardo Martini, Adriano Fazzone, Luca Becchetti
Background:Typically, proteins perform key biological functions by interacting with each other.
no code implementations • 14 Feb 2020 • Michele Gentili, Leonardo Martini, Manuela Petti, Lorenzo Farina, Luca Becchetti
This work proposes a unified framework to leverage biological information in network propagation-based gene prioritization algorithms.