Search Results for author: Leonardo Martini

Found 4 papers, 1 papers with code

Biological Random Walks: multi-omics integration for disease gene prioritization

1 code implementation23 Nov 2022 Michele Gentili, Leonardo Martini, Marialuisa Sponziello, Luca Becchetti

Motivation: Over the past decade, network-based approaches have proven useful in identifying disease modules within the human interactome, often providing insights into key mechanisms and guiding the quest for therapeutic targets.

Retrieval

Network Based Approach to Gene Prioritization at Genome-Wide Association Study Loci

no code implementations28 Oct 2022 Leonardo Martini, Adriano Fazzone, Michele Gentili, Luca Becchetti, Brian Hobbs

Results: We present the Relations-Maximization Method, a dense module searching method to identify putative causal genes at GWAS loci through the generation of candidate sub-networks derived by integrating association signals from GWAS data into the gene co-regulation network.

Network and Sequence-Based Prediction of Protein-Protein Interactions

no code implementations8 Jul 2021 Leonardo Martini, Adriano Fazzone, Luca Becchetti

Background:Typically, proteins perform key biological functions by interacting with each other.

Biological Random Walks: integrating heterogeneous data in disease gene prioritization

no code implementations14 Feb 2020 Michele Gentili, Leonardo Martini, Manuela Petti, Lorenzo Farina, Luca Becchetti

This work proposes a unified framework to leverage biological information in network propagation-based gene prioritization algorithms.

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