no code implementations • 1 Feb 2022 • Madeline Galbraith, Federico Bocci, José N. Onuchic
The Notch-Delta signaling pathway mediates cell differentiation implicated in many regulatory processes including spatiotemporal patterning in tissues by promoting alternate cell fates between neighboring cells.
no code implementations • 27 Nov 2020 • Dongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung, Sukjin Yang, Shubham Tripathi, Madeline Galbraith, Youyuan Deng, Mohit Kumar Jolly, Benny Abraham Kaipparettu, Jose N. Onuchic, Herbert Levine
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis.
no code implementations • 31 Mar 2020 • Bin Huang, Mingyang Lu, Madeline Galbraith, Herbert Levine, Jose N. Onuchic, Dongya Jia
These gene states can be robustly predicted by the stemness GRN but not by randomized versions of the stemness GRN.