DTI-SNNFRA: Drug-Target interaction prediction by shared nearest neighbors and fuzzy-rough approximation

no code implementations • 22 Sep 2020 • Sk Mazharul Islam, Sk Md Mosaddek Hossain, Sumanta Ray

Next, it computes the degree of fuzzy-rough approximations and proper degree threshold selection for the negative samples' undersampling from all possible interaction pairs between drugs and targets obtained in the first stage.

Clustering Drug Discovery

Predicting potential drug targets and repurposable drugs for COVID-19 via a deep generative model for graphs

no code implementations • 5 Jul 2020 • Sumanta Ray, Snehalika Lall, Anirban Mukhopadhyay, Sanghamitra Bandyopadhyay, Alexander Schönhuth

Here, we combine three networks, two of which are year-long curated, and one of which, on SARS-CoV-2-human host-virus protein interactions, was published only most recently (30th of April 2020), raising a novel network that puts drugs, human and virus proteins into mutual context.