1 code implementation • 27 Nov 2019 • Giulio Isacchini, Zachary Sethna, Yuval Elhanati, Armita Nourmohammad, Aleksandra M. Walczak, Thierry Mora
T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and malignancies.
Quantitative Methods
no code implementations • 10 Feb 2015 • Yuval Elhanati, Zachary Sethna, Quentin Marcou, Curtis G. Callan Jr., Thierry Mora, Aleksandra M. Walczak
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Populations and Evolution Genomics
