Mitigating the missing-fragmentation problem in de novo peptide sequencing with a two-stage graph-based deep learning model

1 code implementation • Nature Machine Intelligence 2023 • Zeping Mao, Ruixue Zhang, Lei Xin, Ming Li

Here we reveal that in the process of peptide prediction, missing fragmentation results in the generation of incorrect amino acids within those regions and causes error accumulation thereafter.

de novo peptide sequencing