Identification of Biomarkers Controlling Cell Fate In Blood Cell Development

no code implementations • 17 Sep 2020 • Maryam Nazarieh, Volkhard Helms, Marc P. Hoeppner, Andre Franke

A blood cell lineage consists of several consecutive developmental stages from the pluri- or multipotent stem cell to a state of terminal differentiation.

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection

1 code implementation • 17 May 2020 • Anastasia A. Minervina, Ekaterina A. Komech, Aleksei Titov, Meriem Bensouda Koraichi, Elisa Rosati, Ilgar Z. Mamedov, Andre Franke, Grigory A. Efimov, Dmitriy M. Chudakov, Thierry Mora, Aleksandra M. Walczak, Yuri B. Lebedev, Mikhail V. Pogorelyy

Certain T cell clones were detected in the memory fraction at the pre-infection timepoint, suggesting participation of pre-existing cross-reactive memory T cells in the immune response to SARS-CoV-2.

Specificity

Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones

no code implementations • 25 Oct 2019 • Anastasia A. Minervina, Mikhail V. Pogorelyy, Ekaterina A. Komech, Vadim K. Karnaukhov, Petra Bacher, Elisa Rosati, Andre Franke, Dmitriy M. Chudakov, Ilgar Z. Mamedov, Yuri B. Lebedev, Thierry Mora, Aleksandra M. Walczak

The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections.