NoisET: Noise learning and Expansion detection of T-cell receptors

1 code implementation • 6 Feb 2021 • Meriem Bensouda Koraichi, Maximilian Puelma Touzel, Andrea Mazzolini, Thierry Mora, Aleksandra M. Walczak

High-throughput sequencing of T- and B-cell receptors makes it possible to track immune repertoires across time, in different tissues, in acute and chronic diseases and in healthy individuals.

Immune Fingerprinting through Repertoire Similarity

no code implementations • 24 Jun 2020 • Thomas Dupic, Meriem Bensouda Koraichi, Anastasia Minervina, Mikhail Pogorelyy, Thierry Mora, Aleksandra M. Walczak

Immune repertoires provide a unique fingerprint reflecting the immune history of individuals, with potential applications in precision medicine.

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection

1 code implementation • 17 May 2020 • Anastasia A. Minervina, Ekaterina A. Komech, Aleksei Titov, Meriem Bensouda Koraichi, Elisa Rosati, Ilgar Z. Mamedov, Andre Franke, Grigory A. Efimov, Dmitriy M. Chudakov, Thierry Mora, Aleksandra M. Walczak, Yuri B. Lebedev, Mikhail V. Pogorelyy

Certain T cell clones were detected in the memory fraction at the pre-infection timepoint, suggesting participation of pre-existing cross-reactive memory T cells in the immune response to SARS-CoV-2.

Specificity